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To investigate Lapatinib ditosylate with capecitabine he bing the effectiveness of combination therapy of breast cancer and the security of the third phase of clinical trial, in patients with HER2 overexpression, for patients with breast cancer or metastasis, anthracycline-based antibiotics, and taxanes by invalid patients. Patients were randomly given for lapa, 1 250 mg, 1 times a day, and daily for 14 days in 1 ~ 2 500 mg/m2, 21 d a cycle. Endpoint for tumor progression, 399 patients participated in the experiment, the average age was 53 years old, 14% of patients older than 65 years old, 91% were white, 97% for stage iv breast cancer, 48% of the patients with estrogen receptor or progesterone, 95% are ErbB2 IHC 3 positive IHC 2 positive (fluorescence in situ hybridization method to confirm), 95% of patients after anthracycline-based antibiotics, and by treatment of taxanes. For four months after Mr Rappaport with capecitabine he bing combined treatment group with capecitabine alone he bing tumor progression time were 27.1 and 18.6 weeks [2]. 67 transfer of solid tumor patients, palmer for 8 weeks treatment, found effective for patients by drug resistance, and can extend the time of patients with tumor progression [3]. For clinical trials, Mr Rappaport, 1 800 mg daily dose, patients were well tolerated and effective for a variety of solid tumors, including breast cancer and head and neck cancer [4]. Is 5 - fluorouracil, leucovorin calcium and in accordance with the state for share in the trials for the treatment of tumor, 25 patients with oral, for lapa, giving intravenous above three drugs at the same time, compared with the traditional chemotherapy drug dose by 40%, 19 can evaluate patients, partial response, four, nine stable disease [5]. In the study of malignant salivary gland tumors, for lapa, can extend the tumors in patients with stable period over 6 months, and good patients' tolerance.
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CAS no. : 452-85-7
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